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Investigating thermal dimerization of N-methyl-flindersine. Syntheses and characterizations of paraensidimerines |
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| Authors: | Hui LiYu Tang Richard P Hsung |
| Institution: | a Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China b Division of Pharmaceutical Sciences and Department of Chemistry, 777 Highland Avenue, University of Wisconsin, Madison, WI 53705, United States |
| Abstract: | Thermal dimerization of N-methyl-flindersine is reported here. This work commenced with the intent to access new Diels-Alder-type dimeric bis-pyranylquinoline alkaloids melicodenines but uncovered and characterized naturally occurring paraensidimerine F, F′and C′, as well as two new bis-quinolone derivatives. |
| Keywords: | N-Methyl-flindersine oxa-[3 + 3] Annulation Diels-Alder cycloaddition Thermal dimerization Paraensidimerines Electrocyclic ring-opening |
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