Molecular Recognition of a Peptide by the Nickel(II) Complex of 1,4,7,10‐Tetraazacyclododecane‐2,9‐dione |
| |
Authors: | Jian Gao JosephH Reibenspies Yizhen Sun ArthurE Martell |
| |
Institution: | Jian Gao,Joseph?H. Reibenspies,Yizhen Sun,Arthur?E. Martell |
| |
Abstract: | The nickel(II) complex of the macrocycle 1,4,7,10‐tetraazacyclododecane‐2,9‐dione (dota) was found to be efficient in the recognition of the dipeptide, glycyl‐glycine (Gly‐Gly) in aqueous solution. This (dota)NiII complex serves as a targeting molecule to form a stable ternary complex with the dipeptide at pH 8.3 in aqueous solution. The recognition constant (log K=19.20) and the recognition mechanism were investigated based on the potentiometric method. The single‐crystal of a six‐coordinated (dota)2NiII complex is also reported. |
| |
Keywords: | |
|
|