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Structural study of highly halogenated dihydropyridine derivatives as potential calcium channel modulators |
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| Authors: | Margarita Surez Esperanza Salfrn Estael Ochoa Yamila Verdecia Livan Alba Nazario Martín Carlos Seoane Roberto Martínez‐Alvarez Hector Novoa De Armas Norbert M Blaton Oswald M Peeters Camiel J De Ranter |
| Institution: | Margarita Suárez,Esperanza Salfrán,Estael Ochoa,Yamila Verdecia,Livan Alba,Nazario Martín,Carlos Seoane,Roberto Martínez‐Alvarez,Hector Novoa De Armas,Norbert M. Blaton,Oswald M. Peeters,Camiel J. De Ranter |
| Abstract: | Two dihydropyridines endowed with fluorine atoms ( 3 ) and fluorine and chlorine atoms ( 4 ) have been synthesized and structurally characterized by experimental X‐ray analyses and theoretical calculations at the semiempirical (AMI) and ab initio (HF/6–31G*) levels. The results show that these compounds meet the required criteria to act as potential calcium channel modulators. |
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