Three Tyrosinase Inhibitors and Antioxidant Compounds from Salsola foetida

Phytochemical investigation on the whole plant of Salsola foetida resulted in the isolation of three new phenolic compounds 1, 2 , and 3 , which exhibit tyrosinase inhibition with moderate antioxidant activity. Compounds 1 – 3 inhibited tyrosinase with IC₅₀ 2.61, 1.85, and 0.40 μM , while exhibiting DPPH radical scavenging activity with IC₅₀ 383, 427 and 378 μM , respectively. The structures of 1, 2 , and 3 were determined by modern spectroscopic techniques.