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Synthesis of new uracil non‐nucleoside derivatives as potential inhibitors of HIV‐1
Authors:Farag A El‐Essawy  Nasser R El‐Brollosy  Erik B Pedersen  Claus Nielsen
Abstract:6‐(2‐Phenylethyl) and 6‐cyclohexyl 5‐cyanouracils ( 1a,b ) were synthesized and reacted with chloromethyl ethyl ether, benzyl chloromethyl ether, chloromethyl methyl sulfide and (2‐acetoxyethoxy)methyl bromide. New uracil analogues of (S)‐DHPA were synthesized by reaction of compounds ( 1a,b ) with ((S)‐2,2‐dimethyl‐1,3‐dioxolane‐4‐yl) alkyl p‐toluenesulfonate.
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