A 23Na and 31P NMR investigation of the binding of Ni2+ to Na-DNA |
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| Affiliation: | 1. Precision Medicine - Engineering, Department of Nanoelectronics Engineering, International Iberian Nanotechnology Laboratory, Braga 4715-330, Portugal;2. State Key Laboratory of Analog and Mixed-Signal VLSI, University of Macau, Macao SAR, China;3. School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA;4. Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal;5. Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macao SAR, China;1. Academy of Scientific and Innovative Research (AcSIR)-Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR), G. B. Marg, Bhavnagar 364002, Gujarat, India;2. CSIR-Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research, G. B. Marg, Bhavnagar, 364002, Gujarat, India. |
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| Abstract: | A 23Na and 31P NMR study of the Na-DNA and Na-DNA-Ni systems in aqueous solution has been undertaken. Analysis of the relaxation rates provides evidence that Ni2+ displaces Na+ ions from the condensation layer of Na-DNA. Furthermore, it was found that Ni2+ binds specifically to the DNA phosphate to some extent and that multiple chemical equilibria are involved in the interactions. |
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