Stereoselective synthesis of the atropisomers of myristinin B/C |
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Authors: | Maloney David J Chen Shengxi Hecht Sidney M |
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Affiliation: | Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA. |
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Abstract: | [reaction: see text] The first stereoselective synthesis of a potent DNA damaging agent, (-)-myristinin B/C, has been accomplished. This efficient synthesis allowed for unambiguous confirmation of the structure and absolute stereochemistry of the atropisomeric natural product. The antipode, (+)-myristinin B/C, was also synthesized, providing ample material for biological evaluation of both enantiomers. |
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