Stereoselective synthesis of the atropisomers of myristinin B/C |
| |
Authors: | Maloney David J Chen Shengxi Hecht Sidney M |
| |
Institution: | Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, USA. |
| |
Abstract: | reaction: see text] The first stereoselective synthesis of a potent DNA damaging agent, (-)-myristinin B/C, has been accomplished. This efficient synthesis allowed for unambiguous confirmation of the structure and absolute stereochemistry of the atropisomeric natural product. The antipode, (+)-myristinin B/C, was also synthesized, providing ample material for biological evaluation of both enantiomers. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|