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New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity |
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| Authors: | Stefano Chimichi Marco BoccaliniBarbara Cosimelli Francesco Dall'AcquaGiampietro Viola |
| Affiliation: | a Dipartimento di Chimica Organica ‘U. Schiff’, via della Lastruccia 13, I-50019 Sesto F.no (Firenze), Italy b Dipartimento di Chimica Farmaceutica e Tossicologica, Università Federico II, via Montesano 49, I-80131 Napoli, Italy c Dipartimento di Scienze Farmaceutiche, via Marzolo 5, I-35131 Padova, Italy |
| Abstract: | A convenient route to new 3(2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived human cell lines in comparison to the natural compound geiparvarin. The structure activity relationship indicated that the maximum in vitro antiproliferative activity correlates with the presence of a heterocyclic ring on the ethenyl moiety. |
| Keywords: | 3(2H)-furanones ethenyl-3(2H)-furanones antitumoral compounds |
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