1,3-Diastereocontrol in acyclic radical allylations |
| |
Authors: | Eric J Enholm,Sophie LavieriTanya Cordó va,Ion Ghiviriga |
| |
Affiliation: | Department of Chemistry, University of Florida, Gainesville, FL 32611, USA |
| |
Abstract: | The radical allylation of an acyclic α-hydroxyketone with allyltributyltin under chelation-controlled conditions is reported. Several reaction conditions were explored, including radical initiators, solvents, and temperatures to improve the yield and the diastereomeric ratio. Some Lewis acids, like magnesium bromide etherate and zinc chloride, gave superior diastereomeric ratios (up to 100:1) and good yields. |
| |
Keywords: | free radical diastereoselective allyltributyltin |
本文献已被 ScienceDirect 等数据库收录! |
|