Synthesis of highly substituted tetrahydropyrans: preparation of the C20-C28 moiety of phorboxazoles |
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| Authors: | Tushar K Chakraborty V.Ramakrishna ReddyT.Jagadeshwar Reddy |
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| Affiliation: | Bioorganic Laboratory, Organic Division-III, Indian Institute of Chemical Technology, Tarnaka, Uppal Road, Hyderabad 500 007, India |
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| Abstract: | A propionate-derived polyketide building block A whose 2-methyl-1,3-diol moiety was built by a Ti(III)-mediated ring opening reaction of a trisubstituted 2,3-epoxy alcohol precursor was employed as a common starting material for the syntheses of highly substituted tetrahydropyrans 1-5, the first one being the C20-C28 fragment of cytotoxic natural products, phorboxazoles. |
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| Keywords: | epoxy alcohols Sharpless epoxidation epoxide opening 2-methyl-1,3-diol phorboxazoles |
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