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Chemistry of indoles carrying a basic function. Part 8: A new approach to the ergoline skeleton |
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| Authors: | Mária InczeIstván Moldvai Eszter Temesvári-MajorGábor Dörnyei Mária Kajtár-PeredyCsaba Szántay |
| Institution: | Chemical Research Center, Institute of Chemistry, Hungarian Academy of Sciences, H-1025 Budapest II, Pusztaszeri út 59-67, Hungary |
| Abstract: | Starting from N-pivaloyl-Uhle's ketone a new synthetic approach to the ergoline skeleton has been elaborated. Ring D of the tetracyclic skeleton was formed by an intramolecular Dieckmann-condensation of a diester, obtained in a Reformatsky reaction of a properly substituted derivative of N-pivaloyl Uhle's ketone followed by elimination of water. |
| Keywords: | alkaloids ergolines modified Reformatsky reaction cyclisation Dieckmann condensation |
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