An improved and practical synthesis of 5,5-dimethyl-3-(2-propoxy)-4-(4-methanesulfonylphenyl)-2-(5H)-furanone (DFP—a selective inhibitor of cyclooxygenase-2) |
| |
| Authors: | Srinivas PadakantiManojit Pal Koteswar Rao Yeleswarapu |
| |
| Institution: | Chemistry-Discovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500 050, India |
| |
| Abstract: | DFP, a highly selective and potent COX-2 inhibitor, has been synthesized by a modified approach. Three modifications of the existing method enabled us to prepare DFP in good quantity. |
| |
| Keywords: | anti-inflammatory agents furanones 2-isopropoxyacetic acid |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
