Enzymatic synthesis of optically active 1- and 2-aminoalkanephosphonates |
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| Authors: | Chengye Yuan Chengfu XuYonghui Zhang |
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| Institution: | Shanghai Institute of Organic Chemistry, Chinese Academy of Science 345Lingling Lu, Shanghai 200032, People's Republic of China |
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| Abstract: | A number of 1- and 2-aminoalkanephosphonates were resolved with high enantioselectivity by Candida antarctica lipase B-catalyzed acetylation. By this method, optically pure aminoalkanephosphonates and amidoalkanephosphonates, the precursors of the corresponding aminoalkanephosphonic acids, were synthesized. |
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| Keywords: | aminoalkanephosphonate Candida antarctica lipase B acetylation kinetic resolution |
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