Calixarene amino acids; building blocks for calixarene peptides and peptide-dendrimers

A modular strategy towards receptor macromolecules is presented, which combines synthetically diverse peptide synthesis with highly functional calixarene chemistry. The design and synthesis of calix4]arene amino acids 1a-f, calix-lysines, is described, which were used as construction blocks to assemble nanoscale, multivalent entities—calix-peptides 2 and calix-peptide-dendrimers 3.