a Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, India b Dr. Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad 500 050, India
Abstract:
Tripeptides having a 3-bromobenzyl group at the C-termini and an acryloyl group at the N termini undergo efficient intramolecular Heck reactions to afford the corresponding cyclic peptides in good yields. Synthesis of two such peptides is discussed.