Synthesis and preliminary studies on a novel class of soluble amino alcohol reagents based on methacrylate copolymers |
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| Authors: | Christopher W EdwardsDavid M Haddleton David MorsleyMark R Shipton Martin Wills |
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| Affiliation: | a Department of Chemistry, University of Warwick, Gibbit Hill Road, Coventry CV4 7AL, UK
b GlaxoSmithKline Pharmaceuticals PLC, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK |
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| Abstract: | A class of soluble polymers containing chiral β-amino alcohol ligands, based on methacryate copolymers, are described. The use of copolymers permits the selective introduction of material to control the solubility and a functional group in a controllable ratio and polymer length. The application of the supported polymers to diethylzinc additions is described. |
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| Keywords: | soluble polymers asymmetric catalyst ligand dialkylzinc |
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