Resin-bound aminothiols: synthesis and application |
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Authors: | Spyros MourtasChristina Katakalou Andriana NicolettouChryssoula Tzavara Dimitrios GatosKleomenis Barlos |
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Affiliation: | Department of Chemistry, University of Patras, Patras, Greece |
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Abstract: | Aminothiols were attached through their thiol group onto the 4,4′-dimethoxytrityl (Dmt)-, 4-methoxytrityl (Mmt)-, 4-methyltrityl (Mtt)-, trityl (Trt)- and 2-chlorotrityl (Clt)-resins. The new resins were used in the solid-phase synthesis of aminothiol containing peptides utilizing N-Fmoc amino acids. The synthesized peptides were cleaved from the resins by treatment with trifluoroacetic acid (TFA) solutions using triethylsilane (TES) or ethanedithiol (EDT) as scavengers. |
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