Novel fluorinated amphiphilic cyclodextrin derivatives: Synthesis of mono-, di- and heptakis-(6-deoxy-6-perfluoroalkylthio)-β-cyclodextrins |
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| Authors: | Sandrine PerocheHélène Parrot-Lopez |
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| Institution: | Synthèse, Reconnaissance et Organisation Moléculaire et Biomoléculaire-UMR CNRS 5078, Université Claude Bernard-Lyon I, Domaine Scientifique de la Doua, Bât. J. Raulin, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne cedex, France |
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| Abstract: | A new series of fluorinated amphiphilic β-cyclodextrin derivatives has been synthesized. The strategy is based on the modification of the C-6 position of the mono-6-deoxy-6A-para-tolylsulfonyl, di-6A, 6D-deoxy-6A, 6D-(para-tolylsulfonyl) and heptakis-(6-deoxy-6-iodo)-β-cyclodextrin precursors. The synthesis lead to mono-perfluoroalkylthio-, di-perfluoroalkylthio- and heptakis-perfluoroalkylthio-β-cyclodextrin in excellent yields (90-99%). |
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