First synthesis of 2-[alkylamino(diethoxyphosphoryl)methyl]acrylic ethyl esters |
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| Institution: | a Laboratoire de Chimie Organique et Organométallique, Faculté des Sciences, Campus Universitaire, 2092 Tunis, Tunisia
b University of Nidge, Department of Chemistry, 51200 Nidge, Turkey |
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| Abstract: | The ethyl α-bromomethyl-β-(diethoxyphosphoryl)acrylic acid ester 9 has been prepared by addition of bromine to allylphosphonate 7 then dehydrobromination with DBU in acetonitrile. Reaction of allylic bromide 9 with primary amines in a bimolecular SN2′-type mecanism in methanol at low temperature, gives rise to the 2-alkylamino(diethoxyphosphoryl)methyl]acrylic acid ethyl esters 6. |
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| Keywords: | dimethyl α-(bromomethyl)fumarate 2-[alkylamino(diethoxyphosphoryl)methyl]acrylic acid esters |
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