[6-C]-(2S,4S)-5-Chloroleucine: synthesis and incubation studies with cultures of the cyanobacterium, Lyngbya majuscula |
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| Authors: | William H GerwickPauline Leslie GCliona LongBrian L Marquez Christine L Willis |
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| Institution: | a School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK
b College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA |
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| Abstract: | 6-13C]-(2S,4S)-5-Chloroleucine 12 was prepared in six steps and 26% overall yield from protected l-glutamic acid using 13CH3I as the source of isotopic label. On feeding 12 to cultures of L. majuscula no incorporation of isotopic label into the trichlorinated marine natural product barbamide was detected. The synthesis of a novel dichloroleucine derivative 16 is also described. |
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