Chemoenzymatic synthesis of structured triacylglycerols by highly regioselective acylation |
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Authors: | Arnar HalldorssonCarlos D Magnusson Gudmundur G Haraldsson |
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Institution: | Department of Chemistry, Science Institute, University of Iceland, Dunhaga 3, IS-107 Reykjavik, Iceland |
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Abstract: | A highly efficient two-step chemoenzymatic synthesis of structured triacylglycerols comprising a pure n-3 polyunsaturated fatty acid at the mid-position and a pure saturated fatty acid located at the end-positions is described. In the first step an immobilized Candida antarctica lipase was observed to display an excellent regioselectivity toward the end-positions of glycerol at 0-4°C using vinyl esters as acylating agents. The n-3 fatty acids were introduced into the remaining mid-position highly efficient and in excellent yields using EDCI coupling agent. |
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Keywords: | Candida antarctica lipase EPA DHA lipase regioselectivity structured triacylglycerols vinyl esters |
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