A new ring-opening access to aeroplysinin-1, a secondary metabolite of Verongia aerophoba |
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Authors: | Takahisa OgaminoShigeru Nishiyama |
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Affiliation: | Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan |
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Abstract: | An improved synthetic methodology of spiroisoxazolines by employing anodic oxidation of the corresponding phenol derivative has been established. An alternative efficient synthesis of aeroplysinin-1 1 has been achieved by employing the ring-opening reaction of spiroisoxazolines 10b, 10c as a key step. |
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Keywords: | anodic oxidation ring-opening reaction aeroplysinin Verongia aerophoba |
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