Efficient synthesis of novel dipyridoimidazoles and pyrido[1′,2′;1,2]imidazo[4,5-d]pyridazine derivatives |
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| Authors: | Jean M ChezalEmmanuel Moreau Olivier ChavignonClaire Lartigue Yves BlacheJean C Teulade |
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| Affiliation: | a Faculté de Pharmacie, Chimie Organique, UMR-INSERM 484, 28 place Henri-Dunant, B.P. 38, 63001 Clermont-Ferrand CEDEX 1, France
b Laboratoire de Chimie Organique Pharmaceutique, Faculté de Pharmacie, 15 avenue Ch.-Flahault, 34060 Montpellier, France |
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| Abstract: | Novel dipyrido[1,2-a;3′,4′-d]imidazoles 7a-d, dipyrido[1,2-a;4′,3′-d]imidazoles 8a,c and pyrido[1′,2′;1,2]imidazo[4,5-d]pyridazine derivatives 9a-d were synthesized by two pathways: thermal electrocyclic reaction of 3-alkenylimidazopyridine-2-oximes 10 and direct condensation of ethyl glycinate (or hydrazine) with 2,3-dicarbonylimidazo[1,2-a]pyridines 11. |
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| Keywords: | imidazo[1,2-a]pyridine dipyridoimidazole azacarboline pyridoimidazopyridazine |
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