Synthesis of bridgedhead azolo[3,2-a]pyrimidines and imidazo[2,1-b]thiazines through ring transformation of 2H-pyran-2-ones |
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Authors: | Vishnu Ji Ram Pratibha SrivastavaAtul Goel |
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Institution: | Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India |
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Abstract: | Suitably functionalized 3-carbomethoxy/cyano-2H-pyran-2-ones are excellent synthons for the synthesis of arenes and heteroarenes of therapeutic importance. The compounds 6-aryl-3-cyano-4-methylsulfanyl-2H-pyran-2-ones have been transformed into bridgedhead azolopyrimidines and imidazothiazines through thermal and base-induced ring transformation reactions with aminoazoles and imidazolidin-2-thiones, respectively. |
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Keywords: | azolo[3 2-a]pyrimidine imidazo[2 1-b]thiazines 2H-pyran-2-one |
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