Enantioselective Michael additions of β-keto esters to α,β-unsaturated carbonyl compounds catalyzed by a chiral biquinoline N,N′-dioxide-scandium trifluoromethanesulfonate complex |
| |
| Authors: | Makoto Nakajima Satoshi YamamotoYukiko Yamaguchi Seiichi NakamuraShunichi Hashimoto |
| |
| Institution: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo 060-0812, Japan |
| |
| Abstract: | A catalytic, enantioselective Michael addition of β-keto esters to α,β-unsaturated carbonyl compounds was achieved by using a chiral biquinoline N,N′-dioxide-scandium trifluoromethanesulfonate complex as a catalyst. The corresponding Michael adducts were obtained in high yields and with enantioselectivities up to 84% ee. |
| |
| Keywords: | enantioselectivities α β-unsaturated carbonyl compounds chiral biquinoline enantioselection catalyst Michael addition N-oxide scandium trifluoromethanesulfonate |
| 本文献已被 ScienceDirect 等数据库收录！ |
