Synthesis and combinatorial approach of the reactivity of 6- and 7-arylthieno[3,2-d][1,3]oxazine-2,4-diones |
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Authors: | Franç ois-Xavier Le FoulonEmmanuelle Braud,Fré dé ric FabisJean-Charles Lancelot,Sylvain Rault |
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Affiliation: | Centre d'Etudes et de Recherche sur le Médicament de Normandie 5, rue Vaubénard, 14032 Caen Cedex, France |
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Abstract: | This paper describes a general procedure for the synthesis of new substituted thiaisatoic anhydrides or 6- or 7-aryl-1H-thiéno[3,2-d][1,3]oxazine-2,4-diones 3a-j and 4a-f. They were synthesized in large scale under microwave heating conditions with high yields. The reactivity vs nucleophilic reagents of these compounds was studied and permitted to develop a simple combinatorial procedure to synthesize a library of new thiophene ureidoacids 7a-j and 8a-j. |
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Keywords: | thieno[3,2-d][1,3]oxazine isatoic acid reactivity ureidoacid combinatorial chemistry thiophene |
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