The Meinwald reaction of alkyl propionates. Synthesis of the C1-C9 fragment of aurisides |
| |
Institution: | Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA |
| |
Abstract: | The C1-C9 northern fragment of aurisides 12a was prepared in eight steps and 41% overall yield starting from Grieco's bicyclic lactone (+)-4. The synthesis features a key stereoselective Meinwald reaction of the lithium enolate of alkyl propionate with the functionalized δ-lactone 3. |
| |
Keywords: | Meinwald reaction alkyl propionates aurisides |
本文献已被 ScienceDirect 等数据库收录! |