Biotransformation of triptolide by Cunninghamella blakesleana |
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| Authors: | Lili Ning Jixun ZhanGuiqin Qu Lei ZhongHongzhu Guo Kaishun BiDean Guo |
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| Institution: | a The State Key Lab of Nat and Biomimetic Drugs, School of Pharmaceutical Sciences and Modern Research Center for Traditional Chinese Medicine, Peking University, Beijing 100083, People's Republic of China
b Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, People's Republic of China |
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| Abstract: | Biotransformation of triptolide 1 by Cunninghamella blakesleana (AS 3.970) was carried out. Seven biotransformation products were obtained and four of them were characterized as new compounds. On the basis of their NMR and mass spectral data, their structures were characterized as 5α-hydroxytriptolide 2, 1β-hydroxytriptolide 3, triptodiolide 4, 16-hydroxytriptolide 5, triptolidenol 6, 19α-hydroxytriptolide 7 and 19β-hydroxytriptolide 8. All the new transformed products (2, 3, 7 and 8) were found to exhibit potent in vitro cytotoxicity against some human tumor cell lines. |
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| Keywords: | biotransformation triptolide Cunninghamella blakesleana |
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