Synthetic studies on macrolactin A by using a (diene)Fe(CO)3 complex |
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| Authors: | Akihiro FukudaYusuke Kobayashi Tetsutaro KimachiYoshiji Takemoto |
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| Institution: | a Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
b Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya 663-8179, Japan |
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| Abstract: | The stereoselective synthesis of the two segments 3 and 4 of macrolactin A 1 is described. Macrolactin A is a 24-membered polyene macrolide antibiotic, which is of interest due to a strong activity against B16-F10 murine tumor cell and HIV-1 virus. The key step of the synthesis is the 1,2-migration reaction of a (diene)Fe(CO)3 complex with a introduction of the thiol group to construct the unstable (E,Z)-conjugated dienic moiety (C8-C11). |
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| Keywords: | macrolactin iron-tricarbonyl complex antibiotics antivirus synthesis |
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