Oxidative degradation of eicosapentaenoic acid into polyunsaturated aldehydes |
| |
Authors: | Anne Kristin HolmeideLars Skattebøl |
| |
Institution: | Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, 0315 Oslo, Norway |
| |
Abstract: | Eicosapentaenoic acid is converted in good overall yield to an α,β-ethylenic epoxide derivative. The oxidative cleavage of the epoxide ring with periodic acid in ether proceeded in part with acid-catalyzed rearrangement of the vinyl epoxide moiety prior to cleavage. Among the products were 2E- and 2Z, 5Z, 8Z, 11Z-tetradecatetraenal, 4-hydroxy-2E,6Z,9Z,12Z-pentadecatetraenal and (all-Z)-2-methoxy-3,6,9,12-pentadecatetraenal. |
| |
Keywords: | polyunsaturated aldehydes epoxides Payne type rearrangement |
本文献已被 ScienceDirect 等数据库收录! |
|