Efficient solid-phase synthesis of 4,5-dihydro-1,2,4-triazin-6(1H)-ones |
| |
| Authors: | Damien BoeglinSonia Cantel Jean MartinezJean-Alain Fehrentz |
| |
| Institution: | Laboratoire des Aminoacides, Peptides et Protéines (LAPP), UMR 5810 CNRS Universités Montpellier I et II, Faculté de Pharmacie, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cédex 5, France |
| |
| Abstract: | A new and easy protocol for the formation of substituted 4,5-dihydro-1,2,4-triazin-6(1H)-ones was developed on solid support. The heterocyclic compounds were formed by nucleophilic reaction of hydrazine on thioamide esters. As cyclization was concomitant with cleavage from the support, substituted 4,5-dihydrotriazinones were obtained in high purity. |
| |
| Keywords: | Lawesson's reagent 4 5-dihydrotriazin-6-one thioamide cyclocleavage |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
