首页 | 本学科首页   官方微博 | 高级检索  
     


Stereocontrolled total synthesis of (−)-aspidophytine
Authors:Shinjiro SumiKoji Matsumoto  Hidetoshi Tokuyama  Tohru Fukuyama
Affiliation:a Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
b PRESTO, JST, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Abstract:The enantioselective stereocontrolled total synthesis of aspidophytine is described. The key indole intermediate was prepared by radical cyclization of 2-alkenylphenylisocyanide, followed by Sonogashira-coupling with a highly functionalized terminal acetylene. The 11-membered cyclic amine, a precursor for the formation of the aspidosperma skeleton, was synthesized using nitrobenzenesulfonamide chemistry. After construction of the pentacyclic skeleton, the lactone ring was formed to complete the total synthesis.
Keywords:total synthesis   aspidophytine   indole   aspidosperma alkaloid   macrocycles
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号