Determination of UV filters in packaging by focused ultrasonic solid-liquid extraction and liquid chromatography

A focused ultrasonic solid-liquid extraction (FUSLE) and high performance liquid chromatography (HPLC) with a diode array detector (DAD) is proposed for the determination of ten fat-soluble UV filters in packaging. FUSLE technique is relatively new and has been used for the extraction of a few analytes; such as polycyclic aromatic hydrocarbons and other organic pollutants. In this work, it has been demonstrated that FUSLE is a useful, fast and simple extraction methodology for UV filters because the complete extraction was carried out with just 6ml of tetrahydrofuran and in only one cycle of 30s. The developed method has been validated and applied to the analysis of polyethylene-based multilayer packaging samples. The FUSLE-based method allows the sensitive detection of most of the UV-filters in polyethylene, with limits of detection between 0.4 and 8.5ngmg(-1) (except for BDM). Intra and inter-day relative standard deviation values were below 5 and 14%, respectively, except for MBP. In addition, the proposed method was more efficient than tetrahydrofuran extraction under reflux for 2.5h for all the analytes except for EMT and BDM. Therefore, the developed method can be used to establish the absorption capability of different types of packaging and this information will be very useful in packaging selection.