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The manganese-mediated regioselective chlorination of allenes in synthetic approaches towards the spongistatins and halomon natural products
Affiliation:1. MOSE-DEA, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy;2. Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, D-48149 Münster, Germany;3. Institut für Pharmazeutische Biologie und Phytochemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, D-48149 Münster, Germany;4. Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM), University Münster, Germany;1. Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan;2. School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan
Abstract:The first examples for the chlorination of allenes using manganese reagents generated from potassium permanganate and benzyl triethylammonium chloride in the presence of the chlorine donors oxalyl chloride or chlorotrimethylsilane are reported with the aim of developing useful synthetic routes to the spongistatin and halomon marine natural products.
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