Quantitation of quaternary ammonium compounds using electrospray mass spectrometry |
| |
| Affiliation: | 1. Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L7, Canada;2. Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L7, Canada;3. Suncor Energy, 2489 North Sheridan Way, Mississauga, ON L5K 1A8, Canada;1. Universidad Nacional de Córdoba, Facultad de Ciencias Exactas, Físicas y Naturales, Instituto de Ciencia y Tecnología de los Alimentos (ICTA-FCEFyN-UNC), Av. Vélez Sarsfield 1611, X5016GCA, Córdoba, Argentina;2. nstituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA- UNC-CONICET), Av. Vélez Sarsfield 1611, X5016GCA, Córdoba, Argentina;1. School of Environment and Energy, Peking University Shenzhen Graduate School, University Town, Shenzhen, 518055, China;2. International College Beijing, China Agricultural University, Beijing, 100083, China;3. College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China;4. Environmental Economics and Natural Resources Group, Wageningen University & Research, the Netherlands;5. Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education, College of Environment, Hohai University, Nanjing, 210098, China;1. Department of Chest Diseases, Division of Allergy and Immunology, Ankara University, School of Medicine, Turkey;2. College of Medicine, University of Sharjah, Sharjah, UAE and Department of Pulmonary Medicine, Rashid Hospital, Dubai, United Arab Emirates;3. Chest Medicine Department, Zain Hospital, Kuwait;4. The Medical School, Cairo University, Cairo, Egypt;5. Foxymed, Paris, France;6. MS Health, Rabat, Morocco;7. GlaxoSmithKline, Dubai, United Arab Emirates;1. IPQA, Universidad Nacional de Córdoba, CONICET, Av. Vélez Sarsfield 1611, X5016GCA, Córdoba, Argentina;2. Instituto de Ciencia y Tecnología de los Alimentos − ICTA (FCEFYN, Universidad Nacional de Córdoba), Av. Vélez Sarsfield 1611, X5016GCA, Córdoba, Argentina;3. Planta Piloto de Ingeniería Química, PLAPIQUI (UNS − CONICET), Departamento de Ingeniería Química, UNS, Camino La Carrindanga km. 7, 8000 Bahía Blanca, Argentina;1. Luxembourg Institute of Science and Technology (LIST), Environmental Research and Innovation (ERIN) Department, Esch/Alzette, L-4362, Luxembourg;2. Institute of Biometeorology (IBIMET), National Research Council, Via P. Gobetti, 101-I, 40129 Bologna, Italy;3. Department of Biology, University of British Columbia, Kelowna, British Columbia, V1V 1V7, Canada;4. University of Siena, Department of Life Sciences, Via Pier Andrea Mattioli, 4, 53100, Siena, Italy |
| |
| Abstract: | A sensitive and specific electrospray mass spectroscopic assay has been developed for the quantitation of the series of quaternary ammonium surfactant compounds dodecyltrimethylammonium bromide, tetradecyltrimethylammonium bromide, hexadecyltrimethylammonium bromide, and octadecyltrimethylammonium bromide and neostigmine bromide. Standard solutions were prepared in methanol, with an appropriate quaternary ammonium internal standard used in each case, and injected into a carrier solvent comprising acetonitrile (99%) and methanol (1%). Detection was based upon the positively charged quaternary ammonium ion in each case. Using this new technique, significant increases in sensitivity have been obtained over more traditional gas chromatographic–mass spectroscopic analytical techniques. All of the compounds tested were readily quantifiable at solution concentrations of 50 ppb, with linear correlations (r2>0.995) obtained over the range 50–300 ppb for the alkyltrimethylammonium bromides, and 50–200 ppb for neostigmine bromide. It is envisaged that, using this method, adsorption isotherms for these compounds on highly adsorbing activated carbons should be readily acquired. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
