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A new method for the conversion of enol phenyl thioethers to ketones
Affiliation:1. Early Development and Discovery Sciences, Merck and Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States;2. Early Development and Discovery Sciences, Merck and Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, United States;1. Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, s/n, Barcelona, E-08028, Spain;2. Department of Biosciences and National Research Council (CNR) Biophysics Institute (IBF), University of Milan, Via Celoria 26, 20133 Milan, Italy;3. Departament de Fisicoquímica, Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Prat de la Riba 171, Santa Coloma de Gramenet E-08921, Spain;4. Unitat de Difracció de RX, Centres Científics i Tecnològics (CCiTUB), Universitat de Barcelona, Solé i Sabarís 1-3, Barcelona E-08028, Spain;5. Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium;2. Department of Organic Chemistry, Institute of Chemical Technology, Technická 5, 166 28 Prague, Czech Republic
Abstract:Exposure of enol thioethers at ambient temperature to in situ-generated hydrogen iodide in acetonitrile containing mercuric chloride gives rise to ketones in yields ranging from 74 – 87%.
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