| K~+-FREE INDUCED EARLY AFTERDEPOL-ARIZATION IN CARDIAC VENTRICULAR FIBERS OF GUINEA PIG AFTER COLD TREATMENT |
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| 引用本文： | 王忠民,刘泰槰,刘克球. K~+-FREE INDUCED EARLY AFTERDEPOL-ARIZATION IN CARDIAC VENTRICULAR FIBERS OF GUINEA PIG AFTER COLD TREATMENT[J]. 中国科学B辑(英文版), 1988, 0(12) |
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| 作者姓名： | 王忠民 刘泰槰 刘克球 |
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| 作者单位： | Department of Biology，Peking University，Department of Biology，Peking University，Department of Biology，Peking University |
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| 基金项目： | Project supported in part by the National Natural Science Foundation of China. |
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| 摘 要： | The genesis and elimination of early afterdepolarizations (EADs) have been investigated in guinea pig cardiac ventricular fibers after a short period of cooling (5h, 2—4℃). After rewarming them to 37℃, EADs could be induced by K~+-free superfusion at an appropriate driving stimulation (0.2 Hz) in all preparations. A high level plateau, which linearly increases its duration with time, appears ahead of EADs. The critical point of the plateau occurred steadily at the level of -47±4 mV. Two types of triggered activity, all of which are the rhythmic activities in low level of membrane potential (-50 to -60 mV), appear on the platcau. There is no significant change after overdriving. Agonists of the Na-K pump (K~+ and Tl~+) could stop the rhythmic activity immediately and turn the low level of membrane potential to high one. The results showed that high level plateau is the basis of genesis of EADs, and the activation of Na-K pump plays an important part in stopping triggered rhythms arising from EADs.
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K~+-FREE INDUCED EARLY AFTERDEPOL-ARIZATION IN CARDIAC VENTRICULAR FIBERS OF GUINEA PIG AFTER COLD TREATMENT |
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| WANG ZHONGMIN LIU TAIFENG AND LIU KEQIU. K~+-FREE INDUCED EARLY AFTERDEPOL-ARIZATION IN CARDIAC VENTRICULAR FIBERS OF GUINEA PIG AFTER COLD TREATMENT[J]. Science in China(Chemistry), 1988, 0(12) |
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| Authors: | WANG ZHONGMIN LIU TAIFENG AND LIU KEQIU |
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| Abstract: | |
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| Keywords: | early afterdepolarization triggered aetivity ventrieular fibers low potassium hypothermia. |
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