Cobalt(III)‐Catalyzed Dehydrative [4+2] Annulation of Oxime with Alkyne by CH and NOH Activation |
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Authors: | Malay Sen Deepti Kalsi Prof. Dr. Basker Sundararaju |
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Affiliation: | Fine Chemical Laboratory, Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur (India) |
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Abstract: | Efficient, scalable cobalt‐catalyzed redox‐neutral [4+2] annulation of readily available oximes and alkyne is reported. The developed synthetic methodology is widely applicable and tolerates various functional groups including heterocycles. A stable Cp*CoIII neutral complex is employed as the catalyst for this redox‐neutral [4+2] annulation reaction, which progresses smoothly by way of a reversible cyclometallation without any external oxidizing agent, and produces only water as the side product. |
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Keywords: | annulation C H activation cobalt heterocycles isoquinoline |
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