Direct Catalytic Asymmetric Mannich‐Type Reaction of α‐N3 Amide |
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| Authors: | Zhongdong Sun Dr Karin Weidner Dr Naoya Kumagai Prof Dr Masakatsu Shibasaki |
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| Institution: | Institute of Microbial Chemistry (BIKAKEN), Tokyo, 3‐14‐23 Kamiosaki, Shinagawa‐ku, Tokyo 141‐0021 (Japan) |
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| Abstract: | An α‐N3 7‐azaindoline amide serves as a latent enolate to directly engage in an asymmetric Mannich‐type reaction with N‐thiophosphinoyl imines by the action of a cooperative catalyst. The thus‐obtained highly enantioenriched anti‐adduct was transformed into β‐amino‐α‐azido acid in high yield by simple acidic treatment. |
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| Keywords: | amide asymmetric catalysis azide enantioselective Mannich |
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