| [Cu(dien)Cl]+与核苷酸作用的1H、31P NMR研究 |
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| 引用本文： | 赵刚,吴仲岿,管荫桐,唐雯霞.[Cu(dien)Cl]+与核苷酸作用的1H、31P NMR研究[J].无机化学学报,1993,9(1):7-11. |
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| 作者姓名： | 赵刚 吴仲岿 管荫桐 唐雯霞 |
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| 作者单位： | 南京大学配位化学研究所，配位化学国家重点实验室，南京大学配位化学研究所，配位化学国家重点实验室，南京大学配位化学研究所，配位化学国家重点实验室，南京大学配位化学研究所，配位化学国家重点实验室 南京210008，南京210008，南京210008，南京210008 |
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| 摘 要： | 本文用~1H-NMR和~(31)P-NMR谱研究了Cu(dien)Cl]~+与5＇-AMP、5＇-GMP和5＇-CMP在pD=6.00条件下的共价键合作用.氢核磁共振谱研究表明Cu(dien)]~(2+)与5＇-AMP可以在N-7和N-1位上键合,但N-7是最有利的键合位置.配离子与5＇-GMP、5＇-CMP、分别键合在N-7和N-3位置上.~(31)P核磁共振谱研究结果则表明Cu(dien)]~(2+)还可以与单核苷酸上的磷酸酯根键合.并根据显著加宽质子峰及~(31)P峰的最低Cu(dien)Cl]~+浓度,比较了Cu(dien)]~(2+)对三种核苷酸的碱基与磷酸酯根的亲力.
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| 关 键 词： | 铜 核苷酸 NMR |
| 收稿时间： | 3/7/1991 12:00:00 AM |
1H and 31P NMR STUDIES OF THE INTERACTION OF [Cu(dien)Cl]+ WITH NUCLEOTIDES |
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| Zhao Gang,Wu Zhongkui,Guan Yingtong and Tang Wenxia.1H and 31P NMR STUDIES OF THE INTERACTION OF [Cu(dien)Cl]+ WITH NUCLEOTIDES[J].Chinese Journal of Inorganic Chemistry,1993,9(1):7-11. |
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| Authors: | Zhao Gang Wu Zhongkui Guan Yingtong and Tang Wenxia |
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| Institution: | Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210008,Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210008,Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210008 and Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210008 |
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| Abstract: | The interaction of Cu(dien)Cl]+ with 5'-AMP, 5'-GMP, and 5'-CMPat pD = 6.0 have been studied by 1H and 31P-NMR spectroscopy. The broadening effect of Cu(dien)Cl]+ on the 1H peaks of nucleotides reveal Cu(dien)]2+ binding to N-7 of 5'-GMP and N-3 of 5'-CMP respectively, and binding 5-AMP at N-7 and N-l simultaneously, but N-7 is the mere preferential position. The 31P-NMR spectra indicate that Cu(dien)]2+ can also bind with phosphate of mentioned nucleotides. Comparing the lowest concentration of Cu(dien)Cl]+, at which the apparent broadening of proton and 31P peaks occur, the affinity of Cu(dien)]2+ to the N atoms on bases and the phosphate was discussed. |
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