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A test of location for exchangeable multivariate normal data with unknown correlation
Authors:Follmann Dean  Proschan Michael
Institution:
  • Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive MSC 7609, Bethesda, MD 20892, United States
  • Abstract:We consider the problem of testing whether the common mean of a single n-vector of multivariate normal random variables with known variance and unknown common correlation ρ is zero. We derive the standardized likelihood ratio test for known ρ and explore different ways of proceeding with ρ unknown. We evaluate the performance of the standardized statistic where ρ is replaced with an estimate of ρ and determine the critical value cn that controls the type I error rate for the least favorable ρ in 0,1]. The constant cn increases with n and this procedure has pathological behavior if ρ depends on n and ρn converges to zero at a certain rate. As an alternate approach, we replace ρ with the upper limit of a (1−βn) confidence interval chosen so that cn=c for all n. We determine βn so that the type I error rate is exactly controlled for all ρ in 0,1]. We also investigate a simpler approach where we bound the type I error rate. The former method performs well for all n while the less powerful bound method may be a useful in some settings as a simple approach. The proposed tests can be used in different applications, including within-cluster resampling and combining exchangeable p-values.
    Keywords:62F05  62H15  62H10
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