Asymmetric synthesis of C-aliphatic homoallylic amines and biologically important cyclohexenylamine analogues |
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| Authors: | Ken Lee Chi-Lik Ling Hui Yvonne Loh Teck-Peng |
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| Institution: | Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543. |
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| Abstract: | An efficient method for the asymmetric synthesis of C-aliphatic homoallylic amines with up to 94% yield and 80% de is reported. Ring-closing metathesis of several chiral homoallylic amines using the second-generation Grubbs catalyst provided easy access to a wide variety of cyclohexenylamines. |
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