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Synthesis and Antibacterial Activity of Some Substituted 3-(Aryl)- and 3-(Heteroaryl)indoles |
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| Authors: | Yusuf M. Al-Hiari Ali M. Qaisi Mustafa M. El-Abadelah Wolfgang Voelter |
| Affiliation: | Faculty of Pharmacy, University of Jordan, Amman, Jordan Chemistry Department, Faculty of Science, University of Jordan, Amman, Jordan Abteilung für Physikalische Biochemie des Physiologisch-chemischen Instituts der Universit?t Tübingen, D-72076, Tübingen, Germany |
| Abstract: | Summary. A synthesis of 3-(4-methoxycarbonyl-2,6-dinitrophenyl)indole, its 2,6-diamino analog, and 3-(2-amino-4-trifluoromethyl-6-nitrophenyl)indole is described. 4-(Trifluoromethyl)phenyl derivatives exhibit higher antibacterial potency than the former 4-(methoxycarbonyl)phenyl homologs, while 3-(4-trifluoromethyl-2-nitrophenyl)indole was the most active agent in the series, with MIC ≈ 7 μg/cm3 against E. coli and S. aureus. |
| Keywords: | . 3-(Substituted)phenyl and heteroarylindoles Antibacterial activity. |
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