| 5-磷酰基-3-芳基异噁唑啉的合成及结构表征 |
| |
| 引用本文： | 张长水,叶勇.5-磷酰基-3-芳基异噁唑啉的合成及结构表征[J].有机化学,2012,32(7):1336-1339. |
| |
| 作者姓名： | 张长水 叶勇 |
| |
| 作者单位： | 1. 河南科技大学化工与制药学院 洛阳471003
2. 郑州大学化学系 河南省磷化工工程技术研究中心 郑州450052 |
| |
| 摘 要： | 通过乙烯基膦酸酯与氧化腈的环加成反应,合成了一系列区域专一的异噁唑啉.化合物3c的单晶X衍射证实产物为5-磷酰基异噁唑啉.目标化合物结构经核磁、电喷雾质谱和元素分析表证,生物活性测试表明这些化合物具有一定的神经氨酸酶抑制活性.
|
| 关 键 词： | 乙烯基膦酸酯 氧化腈 环加成反应 异噁唑啉 |
Synthesis and Characterization of 5-Phosphonyl-3-arylisoxazoline |
| |
| Zhang,Changshui
,
Ye,Yong.Synthesis and Characterization of 5-Phosphonyl-3-arylisoxazoline[J].Chinese Journal of Organic Chemistry,2012,32(7):1336-1339. |
| |
| Authors: | Zhang Changshui Ye Yong |
| |
| Institution: | Zhang,Changshuia Ye,Yong,b(aChemical Engineering & Pharmaceutics College,Henan University of Science & Technology,Luoyang 471003)(bPhosphorus Chemical Engineering Research Center of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou 450052) |
| |
| Abstract: | A series of regioselectively isoxazolines were synthesized through cycloaddition reaction of nitrile oxides with vinylphosphonate.The structure of title compound was proved as 5-phosphonyl isoxazoline by X-ray crystallography of compound 3c.Their structures were confirmed by NMR,ESI-MS and elemental analysis.The suppression of the neuraminidase inhibitors was also tested.The result showed that they could inhibit neuraminidase. |
| |
| Keywords: | vinylphosphonates nitrile oxide 1 3-dipolar cycloaddition isoxazoline |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
