| 生物分配色谱:高通量筛选药物膜通透性和活性 |
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| 引用本文： | 孙进,王永军,何仲贵.生物分配色谱:高通量筛选药物膜通透性和活性[J].化学进展,2006(Z2). |
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| 作者姓名： | 孙进 王永军 何仲贵 |
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| 作者单位： | 沈阳药科大学药学院生物药剂学研究室 沈阳110016 |
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| 基金项目： | 国家自然科学基金项目资助(No.30400563) |
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| 摘 要： | 生物分配色谱是指在色谱系统中引入类生物膜结构,以色谱学方法仿真药物与生物膜的相互作用,现已成为评估药物膜通透性和活性的高通量筛选模型。根据最新进展并结合课题组研究内容,对其理论基础、分类及应用进行了评述,并对这一领域的发展和前景进行了展望。
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| 关 键 词： | 生物分配色谱 膜通透性 活性 高通量筛选 |
Biopartitioning Chromatography: High Throughput Screening in Drug Membrane Permeability and Activity |
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| Sun Jin Wang Yongjun He Zhonggui.Biopartitioning Chromatography: High Throughput Screening in Drug Membrane Permeability and Activity[J].Progress in Chemistry,2006(Z2). |
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| Authors: | Sun Jin Wang Yongjun He Zhonggui |
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| Institution: | Sun Jin Wang Yongjun He Zhonggui~ |
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| Abstract: | Biopartitioning chromatography(BPC) emulates drug-membrane interactions by introducing biomembrane-mimetic into chromatographic system,and has become a high throughput screening platform for evaluating drug membrane permeability and biological activity.The theoretical basis,classification and application of BPC are overviewed based on the latest advances and our recent works.The development potential and perspectives of BPC are also discussed. |
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| Keywords: | biopartitioning chromatography(BPC) permeability activity high-throughput screening |
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