Ionic liquid-promoted multi-component reaction: novel and efficient preparation of pyrazolo[3,4-<Emphasis Type="Italic">b</Emphasis>]pyridinone,pyrazolo[3,4-<Emphasis Type="Italic">b</Emphasis>]-quinolinone and their hybrids with pyrimidine nucleoside |
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Authors: | Xinying Zhang Dongfang Li Xuesen Fan Xia Wang Xiaoyan Li Guirong Qu and Jianji Wang |
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Institution: | 1.School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control,Henan Normal University,Xinxiang,People’s Republic of China |
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Abstract: | The utilization of an ionic liquid, bmim]BF4] as both reaction medium and promoter for a multi-component reaction of aldehyde (1) and 5-amino-3-methyl-1-phenylpyrazole (2) with Meldrum acid (3) or dimedone (5) is studied. From this reaction, pyrazolo3,4-b]pyridinone (4) and pyrazolo3,4-b]quinolinone (6) derivatives were prepared in high yields. This novel procedure showed such advantages as environmentally benign nature,
enhanced efficiency, simple operation process, and mild reaction conditions. As an application, the procedure was successfully
used in the preparation of a set of pyrimidine nucleoside–pyrazolo3,4-b]pyridine and pyrazolo3,4-b]quinolinone hybrids with potential biological activities. |
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