The pathophysiology of prospective memory failure after diffuse axonal injury - Lesion-symptom analysis using diffusion tensor imaging |
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| Authors: | Keita Kondo Masaharu Maruishi Hiroki Ueno Kozue Sawada Yukari Hashimoto Tomohiko Ohshita Tetsuya Takahashi Toshiho Ohtsuki and Masayasu Matsumoto |
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| Institution: | 1.Hiroshima Higher Brain Function Center,Hiroshima Prefectural Rehabilitation Center,Taguchi, Saijo,Japan;2.Department of Clinical Neuroscience & Therapeutics,Hiroshima University Graduate School of Biomedical Science,Minami-ku,Japan;3.Department of Psychology,Fukuyama University,Fukuyama,Japan;4.Department of Communication Sciences and Disorders,Hiroshima Prefectural College of Health Sciences,Mihara,Japan |
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| Abstract: | Background Prospective memory (PM) is one of the most important cognitive domains in everyday life. The neuronal basis of PM has been
examined by a large number of neuroimaging and neuropsychological studies, and it has been suggested that several cerebral
domains contribute to PM. For these activation studies, a constellation of experimental PM trials was developed and adopted
to healthy subjects. In the present study, we used a widely used clinical PM assessment battery to determine the lesions attributable
to PM failure, with the hypothesis that lesion-symptom analysis using diffusion tensor imaging (DTI) in subjects with diffuse
axonal injury (DAI) can reveal the neuronal basis of PM in everyday life. |
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