首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Method for the solid-phase parallel synthesis of a 6-alkylamino-2-(functionalized-aminomethyl)-2H-1-benzopyran Library
Authors:Hwang Jong Yeon  Choi Hyung-Sub  Seo Jin-soo  La Hyun-Ju  Yoo Sung-eun  Gong Young-Dae
Institution:Medicinal Science Division, Korea Research Institute of Chemical Technology, Yusung-gu, Daejeon 305-600, Korea.
Abstract:A 2000-member library of benzopyran analogues was prepared by using a solid-phase synthesis protocol. Polymer-bound 6-alkylaminobenzopyrans 7 were synthesized as part of a first generation diversification step by employing reactions of a variety of alkyl halides with the amine 6. Transformations of the resin-bound intermediates 8 formed in this manner by reactions with acid halides, sulfonyl chlorides, and isocyanates leads to introduction of the second level of diversification found in the series of 6-alkylamino-2-(functionalized-aminomethyl)-2-methyl-2H-1-benzopyran analogues 11 and 12.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号