Cobalt coated substrate for matrix-free analysis of small molecules by laser desorption/ionization mass spectrometry |
| |
Authors: | Talat Yalcin Liang Li |
| |
Affiliation: | a Department of Chemistry, Izmir Institute of Technology, Urla-Izmir 35430, Turkey b Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada |
| |
Abstract: | Small molecule analysis is one of the most challenging issues in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. We have developed a cobalt coated substrate as a target for matrix-free analysis of small molecules in laser desorption/ionization mass spectrometry. Cobalt coating of 60-70 nm thickness has been characterized by scanning electron microscopy, energy dispersive X-ray analysis, X-ray diffraction, and laser induced breakdown spectroscopy. This target facilitates hundreds of samples to be spotted and analyzed without mixing any matrices, in a very short time. This can save a lot of time and money and can be a very practical approach for the analysis of small molecules by laser desorption/ionization mass spectrometry. |
| |
Keywords: | Cobalt-coated substrate Matrix-free target Laser Desorption/ionization Small molecule analysis |
本文献已被 ScienceDirect 等数据库收录! |
|